Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia

    February 2012 in “ Journal of Dermatological Science ”
    Chih-Chiang Chen, Cheng Ming Chuong
    Studysummary This review discusses the multiple layers of environmental controls on hair stem cell homeostasis and suggests that targeting these layers could offer safer regenerative medicine therapies without directly using stem cells.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on europepmc.org →
    Discuss this study in the Community →

    Research cited in this study 18

    1. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    2. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    4. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    5. Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit Proceedings of the National Academy of Sciences of the United States of America · 2011
    6. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    7. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    8. Seasonality of Hair Shedding in Healthy Women Complaining of Hair Loss Dermatology · 2009
    9. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    10. Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox Seminars in Cell & Developmental Biology · 2007
    11. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006
    12. Stem Cells and Their Niches Science · 2006
    13. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    14. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    15. Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells British journal of dermatology/British journal of dermatology, Supplement · 1999
    16. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    17. The Role of Prolactin in the Reactivation of Hair Follicles in Relation to Moulting in Cashmere Goats Journal of Endocrinology/Journal of endocrinology · 1994
    18. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992

    Related research 5

    1. Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells Molecules · 2023
    2. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    3. Skipping a Hurdle: Sox2 and Adult Dermal Stem Cells Cell stem cell · 2009
    4. Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles In vitro cellular & developmental biology. Animal · 2008
    5. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008