TLDR Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
The study established an immortalized adult epithelial stem cell line, named Tel-E6E7, derived from keratin 15 positive cells from the human hair follicle bulge region. These cells were cultured for over 30 passages and maintained a stable phenotype for 12 months by expressing human papillomavirus 16 E6/E7 genes. The Tel-E6E7 cell line exhibited similar expression patterns to primary skin stem cells and retained stem cell properties in vitro. The cells demonstrated the ability to differentiate into epidermal, sebaceous gland, and hair follicle lineages, with intact β-catenin dependent signaling, a pathway crucial for hair differentiation. This cell line could provide a consistent model for studying stem cell lineage determination and differentiation in vitro.
Cited in this study
4 / 4 results
16 citations
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January 2007 in “Dermatology” Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.
949 citations
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1010 citations
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139 citations
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15 citations
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321 citations
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66 citations
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57 citations
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