Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles
June 2008
in “
In vitro cellular & developmental biology. Animal
”
immortalized epithelial stem cell line Tel-E6E7 keratin 15 hair follicle bulge region human papillomavirus 16 E6/E7 genes primary skin stem cells epidermal lineage sebaceous gland lineage hair follicle lineage β-catenin dependent signaling hair differentiation HPV 16 E6/E7 genes skin stem cells hair follicle stem cells beta-catenin signaling
TLDR Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
The study established an immortalized adult epithelial stem cell line, named Tel-E6E7, derived from keratin 15 positive cells from the human hair follicle bulge region. These cells were cultured for over 30 passages and maintained a stable phenotype for 12 months by expressing human papillomavirus 16 E6/E7 genes. The Tel-E6E7 cell line exhibited similar expression patterns to primary skin stem cells and retained stem cell properties in vitro. The cells demonstrated the ability to differentiate into epidermal, sebaceous gland, and hair follicle lineages, with intact β-catenin dependent signaling, a pathway crucial for hair differentiation. This cell line could provide a consistent model for studying stem cell lineage determination and differentiation in vitro.
