Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

July 2001 in “ Genes & Development ”

Bradley J. Merrill, Uri Gat, Ramanuj DasGupta, Elaine Fuchs

Tcf3 Lef1 multipotent stem cells skin β-catenin epidermal differentiation follicle outer root sheath Wnt signaling hair-specific keratin genes hair differentiation sebocyte differentiation Tcf3/Lef complexes stem cells skin cells hair cells keratin hair follicles

Studysummary This study found that Tcf3 and Lef1 differently regulate cell differentiation in multipotent skin stem cells, with Tcf3 promoting follicle-like features and Lef1, when modified, promoting sebocyte differentiation.

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