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GlossaryLymphoid Enhancer-Binding Factor 1 (LEF1)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

37 citations, April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

research Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome

1 citations, May 2022 in “International journal of molecular sciences”

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

research Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice

July 2022 in “Journal of Investigative Dermatology”

Lef1 is essential for normal skin, hair growth, and healing wounds in mice.

research Lef1 Expression in Fibroblasts Maintains Developmental Potential in Adult Skin to Regenerate Wounds

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Lef1 helps adult skin cells maintain their ability to heal wounds and regenerate hair, but the study's methods and conclusions have been questioned.

research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

February 2023 in “International Journal of Molecular Sciences”

Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.

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community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.