Search

for
Search:

GlossaryLymphoid Enhancer-Binding Factor 1 (LEF1)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

Lef1 helps stem cells become hair cells by interacting with specific signaling pathways.

research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

37 citations , April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

research Expression Patterns of Hair and Epithelial Keratins and Transcription Factors HOXC13, LEF1, and β-Catenin in a Malignant Pilomatricoma: A Histological and Immunohistochemical Study

27 citations , December 2005 in “Journal of Cutaneous Pathology”

The malignant pilomatricoma showed strong epithelial keratin expression, suggesting it may not calcify.

research TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

22 citations , September 2011 in “Journal of Investigative Dermatology”

TCF/Lef1 is essential for skin barrier function by regulating lipid metabolism.

View more "lef1" in research →

Community Join

1 / 1 results

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.