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GlossarySebocyte Differentiation

process where gland cells mature to produce skin oil

Sebocyte differentiation is the process by which immature cells in the sebaceous glands mature into sebocytes, the cells responsible for producing and secreting sebum, an oily substance that lubricates and protects the skin and hair. This process is crucial for maintaining healthy skin and hair, and disruptions in sebocyte differentiation can lead to skin conditions like acne or seborrheic dermatitis.

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research C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

48 citations, March 2010 in “PloS one”

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

research Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation

36 citations, January 2004 in “European journal of cell biology”

Without keratin 10, there's more growth and development of oil-producing skin cells.

research Androgens Induce Sebaceous Differentiation in Sebocyte Cells Expressing a Stable Functional Androgen Receptor

31 citations, April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations, April 2001 in “Current Biology”

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.

research Y27632 Promotes Proliferation via EGFR Signaling in a Newly Isolated and Characterized Human Primary Sebocyte Cell Line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community dht becoming active since the scalp is tight en cause inflammation

in Research/Science 6 upvotes 2 years ago

User discusses tight scalp causing hair loss and suggests treatments like scalp massages, PRP, saw palmetto, and eucapil. They share their experience with saw palmetto and eucapil and consider adding PRP and scalp massages for better results.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.