Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation
January 2004
in “
European journal of cell biology
”
keratin 10 sebocyte proliferation sebocyte differentiation sebaceous glands sebum wax esters triglycerides cholesterol esters epidermal lipids ceramides cholesterol glycosylceramides sphingomyelin sphingolipid biosynthesis Cer(OS) cornified envelope loricrin involucrin epidermal stem cells K10 sebaceous gland cells skin lipids
TLDR Without keratin 10, there's more growth and development of oil-producing skin cells.
The study provided strong evidence that the targeted deletion of keratin 10 (K10) in mice led to increased proliferation and differentiation of sebocytes, the cells in sebaceous glands. This change was not associated with the induction of proliferation-associated keratins K6, K16, and K17. K10−/− mice exhibited accelerated sebaceous gland cell turnover and increased secretion of sebum, including wax esters, triglycerides, and cholesterol esters. Additionally, levels of major epidermal lipids such as ceramides and cholesterol were elevated, while glycosylceramides and sphingomyelin were reduced, without changes in sphingolipid biosynthesis. The amount of Cer(OS) bound to the cornified envelope, as well as loricrin and involucrin levels, remained unchanged. The study concluded that the altered composition of the suprabasal intermediate filament cytoskeleton in K10−/− mice promoted the differentiation of epidermal stem cells towards the sebocyte lineage.
