Genetically Modified Laboratory Mice with Sebaceous Glands Abnormalities

July 2016 in “ Cellular and Molecular Life Sciences ”

Carmen Ehrmann, Marlon R. Schneider

sebaceous glands PLIN2 EGFR ERBB receptors lipid production hair follicle morphogenesis hair follicle cycling alopecia hair loss skin protection

Studysummary Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

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research Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice

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This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.

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This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

research BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

50 citations , September 2014 in “Stem cell reports”

In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

research Heparan Sulfate Regulates Hair Follicle and Sebaceous Gland Morphogenesis and Homeostasis

42 citations , July 2014 in “Journal of biological chemistry/The Journal of biological chemistry”

This study suggests that heparan sulfate is crucial for regulating hair follicle formation, cycling, and gland morphogenesis, with its ablation leading to continuous hair growth and increased gland activity in mice.

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research A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ

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research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

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research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update

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Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

This study found that mice with a specific loss of DNA methyltransferase 1 showed uneven epidermal thickness, reduced hair regeneration, and progressive alopecia, emphasizing DNA methylation's role in stem cell homeostasis.

research Primary Cicatricial Alopecia: Recent Advances in Understanding and Management

44 citations , November 2011 in “The Journal of Dermatology”

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research Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis

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58 citations , March 2011 in “Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv”

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research The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling

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research Hedgehog Signaling, Keratin 6 Induction, And Sebaceous Gland Morphogenesis

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research Targeted Transgenic Expression of the Mutation Causing Hutchinson-Gilford Progeria Syndrome Leads to Proliferative and Degenerative Epidermal Disease

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research Rac1 Is Crucial for Hair Follicle Integrity but Not Essential for Epidermis Maintenance

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This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.

research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

335 citations , March 2004 in “Development”

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131 citations , March 2004 in “The American journal of pathology”

This study found that modulating BMP activity in transgenic mice affects the development and characteristics of several ectodermal organs, such as skin, hair, and claws, highlighting a stage-dependent influence on organogenesis.

research Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation

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research A Small Deletion Hotspot in the Type II Keratin Gene mK6irs1/Krt2-6g on Mouse Chromosome 15, a Candidate for Causing the Wavy Hair of the Caracul (Ca) Mutation

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research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression

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research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment

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research Expression of Enhancing Factor/Phospholipase A2 in Skin Results in Abnormal Epidermis and Increased Sensitivity to Chemical Carcinogenesis

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research Curly Bare (Cub), a New Mouse Mutation on Chromosome 11 Causing Skin and Hair Abnormalities, and a Modifier Gene (Mcub) on Chromosome 5

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research Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation

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research Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles

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research Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

113 citations , May 2002 in “PubMed”

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research Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors

297 citations , January 2002 in “Development”

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research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables

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research Deregulated Expression of c-Myc Depletes Epidermal Stem Cells

315 citations , June 2001 in “Nature Genetics”

research Abnormal Differentiation of Epidermis in Transgenic Mice Constitutively Expressing Cyclooxygenase-2 in Skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

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research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

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research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations , June 2000 in “The American journal of pathology”

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research A New Mutation Rim3 Resembling Re Den Is Mapped Close to Retinoic Acid Receptor Alpha (Rara) Gene on Mouse Chromosome 11

76 citations , January 1998 in “Mammalian Genome”

research Harlequin Ichthyosis (ICHQ): A Juvenile Lethal Mouse Mutation with Ichthyosiform Dermatitis

27 citations , July 1997 in “PubMed”

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research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

71 citations , May 1996 in “Journal of Investigative Dermatology”

This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.

research Meibomian Gland Changes in the Rhino Mouse

48 citations , July 1988 in “PubMed”

In this study, researchers observed that rhino mice exhibit significant ductal hyperkeratinization in the meibomian gland, which may represent the first naturally occurring disorder of this gland in mice.