Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease

    September 2014 in “ Cell and Tissue Research ”
    Marlon R. Schneider, Ralf Paus
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    TLDR The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.
    The document from 2014 emphasizes the significance of the hair follicle infundibulum in various skin conditions, including acne, hidradenitis suppurativa, and alopecia. It outlines the infundibulum's role in skin immune responses, such as chemokine production and antimicrobial peptide secretion, and its involvement in the pathogenesis of acne vulgaris due to abnormal cell desquamation and microbial colonization. The review highlights recent findings, such as the identification of infundibular markers and epithelial stem cells, which suggest a more active role in hair follicle biology and pathology. It also references specific studies, including Veniaminova et al. (2013) on the loss of the infundibular marker K79 in acne, and Schafer et al. (2014) on the pathogenesis of MADISH-like diseases in mice. The document concludes that further research into the infundibulum could lead to new treatments for common skin diseases.
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