Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice

    February 2014 in “ EMBO molecular medicine ”
    Matthias Schäfer, Ann-Helen Willrodt, Svitlana Kurinna, Andrea Link, Hany Farwanah, Alexandra Geusau, Флориан Грубер, Olivier Sorg, Aaron J. Huebner, Dennis R. Roop, Konrad Sandhoff, Jean‐Hilaire Saurat, Erwin Tschachler, Marlon R. Schneider, Lutz Langbein, Wilhelm Bloch, Hans‐Dietmar Beer, Sabine Werner
    Studysummary This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that prolonged activation of the Nrf2 transcription factor in mouse keratinocytes led to skin abnormalities resembling chloracne/MADISH, characterized by sebaceous gland hyperplasia, hyperkeratosis, acanthosis, hair loss, and large keratinized skin cysts. These effects were linked to increased expression of Nrf2 target genes such as Epgn, Slpi, and Sprr2d, which were also upregulated in human keratinocytes in an Nrf2-dependent manner. The findings highlighted the need to consider these potential side effects when using Nrf2-activating compounds for skin protection and cancer prevention.
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