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Glossary Chloracne

rare skin condition caused by exposure to toxic chemicals

Chloracne is a rare skin condition resembling severe acne, caused by exposure to certain toxic chemicals, particularly chlorinated compounds like dioxins. It manifests as blackheads, cysts, and pustules, primarily on the face, neck, and upper body, and is often associated with occupational or environmental exposure to these harmful substances.

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Research

5 / 397 results

research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

81 citations , February 2014 in “EMBO molecular medicine”

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

research Chloracne: histopathologic findings in one case

18 citations , April 2002 in “Journal of cutaneous pathology”

This study concludes that tiny infundibular cysts, rather than comedones, are the primary lesions in chloracne.

research Do Syrian conflict survivors show novel chronic cutaneous sequelae from chlorine gas exposure: A case report and literature review

September 2025 in “Journal of International Medical Research”

In this case study, researchers documented chronic dermatitis and ulcerative lesions in a 70-year-old Syrian man following chlorine gas exposure during the conflict, highlighting the need for healthcare planning and registries to manage long-term effects in affected populations.

research 12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis

18 citations , December 2016 in “European journal of pharmacology”

In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.

research The chlorine-hair interaction. III. Effect of combining chlorination with cosmetic treatments on hair properties

1 citations , January 1988

This study found that hair treatments applied after chlorination, especially bleaching and dyeing, more significantly altered surface properties and weight loss, while perming most strongly affected tensile properties.

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community Chlorine dioxide: An effective product?

5 upvotes 1 year ago

Chlorine dioxide was discussed as a potential hair growth treatment, with a method involving spraying it on the scalp and covering it with a cap. Concerns were raised about its safety, comparing it to bleach.

community Hair Loss Due To Chlorine and Hard Metals In Water?

in Research/Science 1 upvotes 1 year ago

Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

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