2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

August 2011 in “ Toxicological sciences ”

Carrie Hayes Sutter, Sridevi Bodreddigari, Christina M. Campion, R Wible, Thomas R. Sutter

2,3,7,8-tetrachlorodibenzo-p-dioxin TCDD filaggrin FLG aryl hydrocarbon receptor AHR epidermal differentiation epidermal barrier formation epidermal permeability barrier chloracne

TLDR TCDD speeds up skin barrier formation by increasing certain gene expressions.

The study investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human epidermal differentiation and barrier formation. It was found that TCDD exposure led to increased expression of several prodifferentiation genes, including filaggrin (FLG), by activating the aryl hydrocarbon receptor (AHR) which binds to specific DNA regions upstream of these genes. This activation resulted in enhanced transcription of these genes, as confirmed by reporter assays and immunoblot assays. Additionally, in utero exposure to TCDD accelerated epidermal barrier formation in mouse fetuses by approximately 1 day. The findings suggested that the epidermal permeability barrier is a functional target of TCDD-activated AHR, providing insights into the mechanisms underlying chloracne pathology.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

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community My slick bald temples ( for about 7-8 years ) FIN MIN KETO MICRONEEDLING 2 months +

in Progress Pictures 54 upvotes 3 years ago

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in Progress Pictures 264 upvotes 1 month ago

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community Losing gains from 7 months of oral min, fin, dut.

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community Am I going nuts or this is crazy 8 days recovery? (22yo)

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research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation

April 2017 in “Journal of Dermatological Science”

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