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Glossary Filaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

Related Terms

Keratohyalin Granules

Research

5 / 843 results

research Expression of epidermal keratins and filaggrin during human fetal skin development.

292 citations , October 1985 in “The Journal of Cell Biology”

This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.

research Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation

34 citations , August 2019 in “Journal of Allergy and Clinical Immunology”

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

research Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

23 citations , February 2015 in “The American journal of pathology”

This study found that the absence of sebaceous glands may be an early factor in the development of keratosis pilaris, leading to hair shaft and skin barrier abnormalities, independent of filaggrin mutations.

research Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types

15 citations , January 2012 in “Journal of Veterinary Science”

This study examined variations in epidermal thickness and protein expression across different dog breeds, finding significant differences by anatomical site and breed, with associated mRNA and protein expression changes observed.

research Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification

12 citations , June 2013 in “International Journal of Dermatology”

This study found that different types of seborrheic keratosis demonstrate diverse differentiation patterns, highlighting its undifferentiated and hyperproliferative state with varying keratinization directions.

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