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GlossaryFilaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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research Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

23 citations, February 2015 in “The American journal of pathology”

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

research Filaggrin Mutations as an Archetype for Understanding the Pathophysiology of Atopic Dermatitis

3 citations, August 2014 in “Journal of The American Academy of Dermatology”

Filaggrin mutations are linked to atopic dermatitis and help explain how genetics and environment affect the disease.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

3 citations, July 2011 in “Folia Histochemica et Cytobiologica”

Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.

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September 2007 in “Journal of Investigative Dermatology”

ANp63 is crucial for skin integrity, new filaggrin gene mutations link to eczema, hair can regrow from non-stem cells, sunburns are increasing, and glucocorticoids help treat skin allergies by affecting immune cells.

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations, April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

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community High Estrogen causing hair loss?

in Treatment 15 upvotes 1 year ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

community Father trying to save his 17 year old son from MPB

in Progress Pictures 160 upvotes 2 years ago

Father assists son with hair loss using Finasteride Propecia. Son's hair improves, considers adding Minoxidil or Dutasteride for better results.