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GlossaryFilaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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research Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency

23 citations , February 2015 in “The American journal of pathology”

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

research Epithelial Keratin and Filaggrin Expression in Seborrheic Keratosis: Evaluation Based on Histopathological Classification

12 citations , June 2013 in “International Journal of Dermatology”

Seborrheic keratosis shows varied cell differentiation, and keratin analysis helps diagnose skin tumors.

research Filaggrin Mutations as an Archetype for Understanding the Pathophysiology of Atopic Dermatitis

3 citations , August 2014 in “Journal of The American Academy of Dermatology”

Filaggrin mutations are linked to atopic dermatitis and help explain how genetics and environment affect the disease.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

3 citations , July 2011 in “Folia Histochemica et Cytobiologica”

Calcium reduces involucrin in rat hair bulbs but doesn't affect filaggrin and Kdap.

research Expression of Epidermal Keratins and Filaggrin During Human Fetal Skin Development

292 citations , October 1985 in “The Journal of Cell Biology”

Keratins and filaggrin change as fetal skin develops, marking key stages of skin formation.

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community What new hair-loss treatments actually look exciting right now (Oct 2025)

in Research/Science 167 upvotes 1 month ago

New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.

community Son, 19: One year of Fin and Min but not seeing results?

in Finasteride/Dutasteride 21 upvotes 4 months ago

A 19-year-old has been using oral finasteride and minoxidil for a year without noticeable results. Suggestions include adding derma-stamping, increasing ketoconazole shampoo use, and considering vitamin D testing, while acknowledging that response times vary.

community Story time! The Great Unbalding (PP405)

in Research/Science 229 upvotes 4 weeks ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

community The guys at /bald are allergic to hair regrowth

in Satire 101 upvotes 1 month ago

Some embrace baldness, while others promote treatments like minoxidil and finasteride. Opinions differ on accepting baldness versus pursuing hair regrowth.

community High Estrogen causing hair loss?

in Treatment 14 upvotes 2 years ago

A 24-year-old male using topical finasteride for hair loss is experiencing thinning despite treatment and has high estrogen levels. He is seeking advice on whether high estrogen could be causing hair loss and how others with high estrogen levels have addressed it.

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