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    Glossary Filaggrin

    protein crucial for skin barrier function and hydration

    Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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    1. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    2. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    3. Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency ˜The œAmerican journal of pathology · 2015 · 23 citations
    4. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
    5. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification International Journal of Dermatology · 2013 · 12 citations
    6. Biochemical examination of fetal skin biopsy specimens obtained by fetoscopy: Use of the method for analysis of keratins and filaggrin Prenatal Diagnosis · 1986 · 7 citations
    7. Filaggrin mutations as an archetype for understanding the pathophysiology of atopic dermatitis Journal of The American Academy of Dermatology · 2014 · 3 citations
    8. Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation Folia Histochemica et Cytobiologica · 2011 · 3 citations
    9. FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures Frontiers in Genetics · 2025 · 1 citations
    10. Recombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells International Journal of Biological Macromolecules · 2026
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