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GlossaryKeratohyalin Granules

tiny structures in skin cells aiding keratin production

Keratohyalin granules are tiny structures found in the cells of the outer layer of the skin, specifically in the stratum granulosum. They play a crucial role in the process of keratinization, where skin cells produce keratin, a protein that helps form a protective barrier. These granules contain proteins like filaggrin, which help in the aggregation of keratin filaments, contributing to the skin's strength and resilience.

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research Existence of Trichohyalin-Keratohyalin Hybrid Granules: Co-Localization of Two Major Intermediate Filament-Associated Proteins in Non-Follicular Epithelia

54 citations , November 1994 in “Differentiation”

Trichohyalin is found in non-hair tissues and works with filaggrin in certain skin areas and conditions.

research Fine Structure of the Fully Keratinized Hair Cuticle in Human Head Hair

11 citations , January 1981 in “Cells Tissues Organs”

Human hair cuticle has five cell layers with specific junctions and granules.

research FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice

58 citations , November 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The Foxn1 gene is essential for normal nail and hair development.

research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain During Epidermal Differentiation

25 citations , October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

research Distribution of Caspase-14 in Epidermis and Hair Follicles Is Evolutionarily Conserved Among Mammals

21 citations , September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology”

Caspase-14 is important for skin and hair development in all mammals.

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