TLDR Sorafenib can cause facial acne-like eruptions, which improve after reducing the dose or stopping the drug.
Sorafenib, an oral multikinase inhibitor, was associated with facial acneiform eruptions in five patients, typically appearing after 4 weeks of treatment at a dose of 400 mg twice daily. The eruptions resembled chloracne in three patients and presented as papules and pustules in two others. Topical treatments provided partial improvement, but significant improvement or resolution occurred after reducing the dose or discontinuing sorafenib. This cutaneous adverse event was rare and observed in patients with various cancers, including liver epithelioid hemangioendothelioma, metastatic renal cell carcinoma, and hepatocellular carcinoma.
11 citations
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December 2013 in “Clinical and Experimental Dermatology” Sorafenib often causes skin side effects, indicating effective cancer treatment.
13 citations
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June 2008 in “International Journal of Dermatology” Sorafenib can cause a unique skin reaction.
192 citations
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January 2015 in “Journal of the American Academy of Dermatology” Targeted cancer therapies often cause serious skin problems that need careful management.
Low-dose sorafenib can cause severe facial acne, treatable with topical medication.
19 citations
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October 2011 in “Clinics in Dermatology” New chemotherapy drugs cause skin side effects, but treatments like minocycline and tetracycline can help reduce them.
December 2025 in “Biomedicines” Tyrosine kinase inhibitors for endocrine tumors often cause skin issues, requiring early management and treatment adjustments.
1 citations
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March 2019 in “Actas Dermo-Sifiliográficas” New cancer treatments are less harmful to hair but can still cause hair loss, color, shape, and growth changes.
