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Glossary Sorafenib

medication that inhibits proteins to slow cancer growth

Sorafenib is a medication primarily used to treat certain types of cancer, such as liver, kidney, and thyroid cancers. It works by inhibiting multiple proteins involved in tumor cell growth and angiogenesis (the formation of new blood vessels that supply the tumor), thereby slowing the progression of the disease.

Research

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research Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis

215 citations , March 2011 in “Clinical Cancer Research”

This study found that sorafenib was active against desmoid tumors, with 25% of patients achieving a partial response and 70% maintaining stable disease.

research Molecular targeted therapies for cancer: Sorafenib monoï¿½therapy and its combination with other therapies (Review)

46 citations , February 2012 in “Oncology Reports”

This review summarizes existing studies on sorafenib, noting its promising effects in some cancers, but also highlights its limitations and potential synergy when combined with other anticancer treatments.

research Hand-Foot and Stump Syndrome to Sorafenib

45 citations , January 2007 in “Journal of Clinical Oncology”

This case report identifies hand-foot and stump syndrome as a potential side effect of sorafenib therapy in a 47-year-old man with a leg amputation.

research Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea

39 citations , June 2019 in “Frontiers in Endocrinology”

This study reported that while both sorafenib and lenvatinib may require dose modifications due to adverse events in treating advanced or metastatic thyroid cancers, key differences in side effect profiles were observed.

research Sorafenib-induced eruption resembling pityriasis rubra pilaris

21 citations , July 2011 in “Journal of the American Academy of Dermatology”

This study reported a drug-induced pityriasis rubra pilaris-like eruption in a patient treated with sorafenib, suggesting a possible effect of sorafenib on keratinocyte biology.

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