Cutaneous Adverse Effects of Targeted Therapies

January 2015 in “ Journal of the American Academy of Dermatology ”

James B. Macdonald, Brooke Macdonald, Loren E. Golitz, Patricia LoRusso, Aleksandar Sekulić

cutaneous adverse effects epidermal growth factor receptor KIT BCR-ABL angiogenesis multikinase inhibitors

TLDR Targeted cancer therapies often cause serious skin problems that need careful management.

The document discussed the rapid development of targeted therapies in oncology and their associated cutaneous adverse effects. Dermatologists needed to be aware of these skin-related toxicities, which were common and could be severe enough to limit dosage or discontinue therapy. The article emphasized the importance of understanding the mechanisms and recognizing symptoms to manage these toxicities effectively. It specifically reviewed skin-related adverse effects of inhibitors targeting the cell membrane, including epidermal growth factor receptor, KIT, BCR-ABL, angiogenesis, and multikinase inhibitors.

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Cutaneous Adverse Effects of Targeted Therapies

Research cited in this study

research Understanding, Recognizing, and Managing Toxicities of Targeted Anticancer Therapies

research Dasatinib-Induced Leukotrichia in a Patient With Chronic Myelogenous Leukemia

research A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib

research Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

research The Management of EGFR Inhibitor Adverse Events: A Case Series and Treatment Paradigm

research A Case of Cicatricial Alopecia Associated with Erlotinib

research Cetuximab-Associated Elongation of the Eyelashes

research A Case Report of Inflammatory Nonscarring Alopecia Associated with the Epidermal Growth Factor Receptor Inhibitor Erlotinib

research Gefitinib-Induced Hair Alterations: Figure 1

research Skin Toxicity Caused by EGFR Antagonists: An Autoinflammatory Condition Triggered by Deregulated IL-1 Signaling?

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

research Tyrosine Kinase Inhibition and Grey Hair

research Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

research Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition

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