A Case of Cicatricial Alopecia Associated with Erlotinib

    January 2011 in “ Annals of Dermatology ”
    Bo Yang, Chan Yl Bang, Ji Won Byun, Sung Hyub Han, Hee Jin Song, Seung Gyun In, Jeong Hyun Shin, Gwang Seong Choi
    TLDR Erlotinib can cause hair loss as a side effect.
    Erlotinib, a tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR), was primarily used to treat non-small cell lung cancer. However, EGFR also played a crucial role in skin and hair growth and differentiation, leading to various skin-related side effects when using EGFR-TKIs. These side effects included follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and changes in hair texture. This document reported a rare case of a 61-year-old woman who developed cicatricial alopecia after being treated with erlotinib, highlighting a potential adverse effect of the drug on hair health.
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