EGFR Inhibitors and Cutaneous Complications: A Practical Approach to Management

September 2017 in “ Oncology and therapy ”

Lauren Guggina, Andrew Choi, Jennifer N. Choi

EGFR inhibitors epidermal growth factor receptor inhibitors papulopustular eruptions xerosis pruritus mucositis radiation dermatitis

Studysummary This review discusses the common dermatologic side effects of epidermal growth factor receptor inhibitors and provides practical guidance for recognizing and managing these effects; it reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Cutaneous Adverse Effects of Targeted Therapies

192 citations , January 2015 in “Journal of the American Academy of Dermatology”

This review discusses skin-related toxicities associated with targeted cancer therapies and emphasizes the need for dermatologists to understand and manage these adverse effects, but reports no new experimental results.

research The Management of EGFR Inhibitor Adverse Events: A Case Series and Treatment Paradigm

32 citations , January 2012 in “International Journal of Dermatology”

This study reported that the most common skin side effect of epidermal growth factor receptor inhibitors was a papulopustular rash, treatable with symptom-targeted therapies, while drug suspension was rarely needed.

research A Case of Cicatricial Alopecia Associated with Erlotinib

25 citations , January 2011 in “Annals of Dermatology”

This case report documents a 61-year-old woman treated with erlotinib who experienced the rare side effect of cicatricial alopecia.

research Cetuximab-Associated Elongation of the Eyelashes

30 citations , August 2010 in “American Journal of Clinical Dermatology”

This article reviews eyelash elongation as a side effect of EGFR inhibitors in cancer treatment, finding that the condition is typically not severe and may be managed by trimming.

research A Case Report of Inflammatory Nonscarring Alopecia Associated with the Epidermal Growth Factor Receptor Inhibitor Erlotinib

33 citations , June 2009 in “Journal of Cutaneous Pathology”

This article discusses the cutaneous side effects of erlotinib, an EGFR inhibitor, in a patient with non-small cell lung cancer, reporting nonscarring alopecia and indicative scalp biopsy findings.

research Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

138 citations , February 2007 in “European journal of cancer”

This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.

research Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin

193 citations , June 1990 in “Journal of Investigative Dermatology”

research Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition

114 citations , September 1985 in “Journal of Investigative Dermatology”