Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

    November 1995 in “ The EMBO Journal ”
    Rodolfo Murillas, Fernando Larcher, Claudio J. Conti … José L. Jorcano
    Studysummary Blocking EGFR in mice causes hair loss and skin changes.
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    Research cited in this study 10

    1. Fibroblast Growth Factor and Epidermal Growth Factor in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    2. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    3. The Secret Life of the Hair Follicle Trends in genetics · 1992
    4. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991
    5. Growth Factors Specifically Alter Hair Follicle Cell Proliferation and Collagenolytic Activity Alone or in Combination Differentiation · 1990
    6. Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin Journal of Investigative Dermatology · 1990
    7. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984
    8. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle Journal of Investigative Dermatology · 1984
    9. Distribution and Number of Epidermal Growth Factor Receptors in Skin Is Related to Epithelial Cell Growth Developmental Biology · 1983
    10. Epidermal Growth Factor Delays Development of Epidermis and Hair Follicles in Mice During First Coat Growth The Anatomical Record · 1983

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