Growth Factors Specifically Alter Hair Follicle Cell Proliferation and Collagenolytic Activity Alone or in Combination

    December 1990 in “ Differentiation ”
    Wendy C. Weinberg, Peter de Nully Brown, William G. Stetler‐Stevenson, Stuart H. Yuspa
    TLDR Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.
    The study utilized a three-dimensional culture model to investigate the effects of growth factors on murine hair follicle cell proliferation and collagenolytic activity. It was found that transforming growth factor-alpha (TGF-α) stimulated DNA synthesis in a dose-dependent manner, particularly in outer root sheath cells, while TGF-β1 and TGF-β2 inhibited this proliferation and countered TGF-α's effects. Epidermal growth factor (EGF) and TGF-α promoted collagen gel lysis, whereas TGF-β1, TGF-β2, and cholera toxin did not. The study also noted that combinations of EGF or TGF-α with TGF-β1 or TGF-β2 enhanced collagenase release, with 92-kDa and 72-kDa type IV procollagenases being predominant. These findings suggested that growth factors could have synergistic or opposing roles in hair follicle development, influencing cell replication and dermal invasion.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 2 years ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  11 upvotes 1 year ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    3 / 3 results