Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro

    November 1987 in “ Differentiation ”
    Hans‐Jürgen Stark, Dirk Breitkreutz, Alain Limat, Paul E. Bowden, Norbert E. Fusenig
    TLDR Outer root sheath cells consistently express certain keratins influenced by their environment.
    The study analyzed keratins produced by different compartments of the human hair follicle and compared them to those produced by cultured hair follicle and interfollicular keratinocytes. It identified five major keratins consistently expressed in the outer root sheath (ORS) cells both in vivo and in vitro, which were similar to those expressed by interfollicular epidermis keratinocyte cultures. The research demonstrated that the microenvironment influences the differentiation of ORS cells, leading to the consistent expression of "basal" and "hyperproliferative" keratins. This suggests that while the environment directs keratin expression, other environmental responses may occur, such as during skin wound healing by ORS cells.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 162 results

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 6 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

      community Shampoo except ketoconazole that works

      in Product  8 upvotes 1 year ago
      The conversation is about seeking shampoos that help with hair loss or hair thickening without ketoconazole, suggesting alternatives like minoxidil, finasteride, or stemoxydine. One reply suggests that most hair loss shampoos don't work as claimed.

      community Topical Dutasteride. Does it work?

      in Finasteride/Dutasteride  13 upvotes 1 year ago
      Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

      community Should I get transplant #4 or just shave my head?

      in Transplants  171 upvotes 1 year ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

      community Keratin fibers vs. Gossypium Herbaceum Hair fibers

      in Product  1 upvotes 1 year ago
      The conversation is about comparing keratin hair fibers to Gossypium Herbaceum hair fibers for diffuse hair loss. The user prefers keratin fibers for their durability and is seeking a bulk purchase option.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 1 year ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

    Related Research

    8 / 8 results