Expression of Caspase-14 and Keratin-19 in the Human Epidermis and Appendages During Fetal Skin Development
February 2013
in “
Archives of Dermatological Research
”
Research cited in this study
8 / 8 resultsresearch Distribution of Caspase-14 in Epidermis and Hair Follicles Is Evolutionarily Conserved Among Mammals
This study reports that caspase-14's expression pattern in the epidermis and hair follicles is highly conserved across diverse mammalian species, suggesting its early evolutionary role in mammalian skin maturation.
research Keratins of the Human Hair Follicle
More research is needed to understand how hair keratins work and their role in hair disorders.
research Human Follicular Stem Cells: Their Presence in Plucked Hair and Follicular Cell Culture
This study found CK19/Bcl-2-positive and Bax-negative cells in hair follicle cultures from plucked hairs, supporting their potential identification as follicular stem cells located in the bulge area.
research Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage
This study found that keratin 19 may be a marker for skin stem cells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.
research Localization of Merkel Cells at Hairless and Hairy Human Skin Sites Using Keratin 18
This study localized Merkel cells in human skin, finding them in the basal layer of glabrous skin at palms and soles, and in the interfollicular epidermis and isthmus region of hair follicles.
research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues
This study found that T cytokeratins appear more gradually and with complex coexpression patterns in developing nail structures compared to the more abrupt transition in hair follicles.
research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)
This study found that trichocytic cytokeratins, typically found in hair, are also present in nails, filiform papillae of the tongue, and the epithelial reticulum of the thymus.
research Expression of Epidermal Keratins and Filaggrin During Human Fetal Skin Development
This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.
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4 / 4 resultsresearch Delayed Wound Healing in Keratin 6a Knockout Mice
This study found that MK6a-deficient mice showed delayed reepithelialization after superficial wounding but not after full-thickness skin wounds, suggesting MK6a plays a role in activating follicular keratinocytes post-wounding.
research Keratin and Skin Disorders
This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.
research Keratin Expression in Basal Cell Carcinomas
The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.
research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation
This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.