Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum)
May 1988
in “
Differentiation
”
TLDR Trichocytic cytokeratins are found in hair, nails, tongue, and thymus cells, showing complex regulation in tissue development.
The study demonstrated that trichocytic cytokeratins, typically found in hair-forming cells, were also present in cells forming nails, the filiform papillae of the tongue, and some cells in the thymus of both humans and bovines. Using biochemical methods and immunofluorescence microscopy, researchers identified that these cytokeratins, including two newly discovered components, were expressed alongside epithelial cytokeratins in certain cells. This coexpression in hair follicles, nail matrix and bed, lingual papillae, and the thymus suggests a complex regulatory control of cytokeratin synthesis during tissue development and differentiation. The findings highlighted the potential functional significance of trichocytic cytokeratins in diverse tissues.
