Keratin Cytoskeletons in Epithelial Cells of Internal Organs
June 1979
in “
Proceedings of the National Academy of Sciences
”
New to Keratin? There is a guide in the encyclopedia. Read the guide → Studysummary This study demonstrated that keratin is widely present in various epithelial cells, providing structural strength and potential insights into the origin of cell lines.
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The study used an antiserum against human epidermal keratins to detect keratins in various rabbit and human tissues through indirect immunofluorescence. Strong keratin staining was observed in stratified squamous epithelia, epidermal appendages, and certain epithelial cells of the intestinal, urinary, female genital, and respiratory tracts, as well as in the fine ductal system of the pancreas and submaxillary gland. No staining occurred in fibroblasts, muscle, cartilage, blood vessels, nerve tissue, or kidney cells. The findings indicated that keratins formed a cytoskeleton in epithelial cells, providing structural strength, and that keratin staining could help determine the origin of cell lines.
