Immunological Characteristics and Histological Distribution of Human Hair Fibrous Proteins Studied with Anti-Hair Keratin Monoclonal Antibodies HKN-2, HKN-4, and HKN-6

    February 1986 in “ Journal of Histochemistry & Cytochemistry ”
    Masayoshi Ito, Toshio Tazawa, Keita Ito, Naoya Shimizu, Koji Katsuumi, Yukari Sato
    TLDR Some hair proteins are specific to hair, while others are also found in skin cells.
    The study produced monoclonal antibodies HKN-2, HKN-4, and HKN-6 to investigate the immunological characteristics of human hair fibrous proteins. HKN-2 and HKN-4 marked both hair and epidermal fibrous proteins, while HKN-6 was specific to hair proteins. Immunohistochemical analysis showed that all three antibodies stained the keratogenous zone of anagen hairs, with HKN-6 being highly specific to hair and not reacting with other skin or organ tissues. HKN-2 reacted with various skin epithelial tissues, and HKN-4 showed broad cross-reactivity with epithelial cells in the skin and other organs. The study concluded that some hair fibrous protein components were specific to hair cells, while others cross-reacted with epithelial cells, suggesting the antibodies' utility in examining epithelial cell differentiation.
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