Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

    December 1986 in “ ˜The œjournal of cell biology/˜The œJournal of cell biology ”
    Marion H. Lynch, W. Michael O’Guin, Carolyn Hardy, Lung‐Yi Mak, Tung‐Tien Sun
    Image of study
    TLDR Hair and nail cells share similar proteins, indicating a common differentiation pathway.
    The study investigated the distribution and expression of various human hair proteins in the hair follicle using mouse monoclonal antibodies. It found that acidic 44K/46K and basic 56-60K keratins co-appeared in upper cortical and cuticle cells, while 10-25K high sulfur proteins were present only in matured cortical cells. Inner root sheath cells did not react with any antibodies, indicating immunological differences from cortex and cuticle filaments. Additionally, the nail plate contained 10-20% soft keratins along with hair keratins. These findings suggested that hair cortex and nail plate precursor cells share a differentiation pathway, with the 44K/46K and 56-60K keratins serving as markers for hair/nail-type epithelial differentiation.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 26 results

      community PP405 is NOT gray market jxl069

      in Technology  24 upvotes 2 weeks ago
      PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

      community Topical Min 5% - Keto 2% shampoo 2x week - Tretnoin 0.025% - 6 Months update

      in Is this regrowth?  13 upvotes 6 months ago
      The user is experiencing hair loss and has been using topical Minoxidil 5%, Keto 2% shampoo, and Tretinoin 0.025% for six months, with plans to start topical Finasteride 0.1% soon. They are advised to focus on DHT blockers like Finasteride and consider additional tests and supplements to address potential deficiencies and scalp health.

      community Minoxidil works only with Retinoic acid

      in Minoxidil  319 upvotes 6 months ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

      community Genuine Minoxidil Sanity Check-Tiktok Shops

      in Minoxidil  187 upvotes 7 months ago
      A user bought Kirkland Minoxidil from a TikTok shop and sought confirmation of its authenticity through a bleach test, which some users warned could be dangerous. Many participants advised against buying from TikTok due to the risk of fakes, suggesting alternatives like buying from Costco or reputable online pharmacies.

    Related Research

    6 / 6 results