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    Glossary Epithelial Differentiation

    process where cells become specialized to form body linings

    Epithelial differentiation is the process by which unspecialized cells develop into specialized epithelial cells that form the lining of surfaces and cavities in the body, such as the skin, hair follicles, and internal organs. This process is crucial for creating barriers and structures that protect the body and facilitate functions like absorption, secretion, and sensation.

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    1. Wnt signaling induces epithelial differentiation during cutaneous wound healing BMC Cell Biology · 2006 · 159 citations
    2. TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition Cold Spring Harbor Perspectives in Biology · 2017 · 82 citations
    3. Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy Stem Cell Research & Therapy · 2020 · 48 citations
    4. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells Biochemical and Biophysical Research Communications · 2006 · 28 citations
    5. Suprabasal change and subsequent formation of disulfide-stabilized homo- and hetero-dimers of keratins during esophageal epithelial differentiation Journal of Cell Science · 1993 · 28 citations
    6. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    7. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    8. Defining the complex epithelia that comprise the canine claw with molecular markers of differentiation Veterinary Dermatology · 2009 · 6 citations
    9. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    10. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium Mechanisms of Development · 2004 · 56 citations
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    1. Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling Reddit · 26 Oct 2025

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