← Learn

    Osteopontin

    Osteopontin (OPN), also known as bone /sialoprotein I, early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene. The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 10

    1. Relation of urinary stone disease with androgenetic alopecia and serum testosterone levels Urolithiasis · 2016 · 6 citations
    2. Basal Cell Carcinoma With Matrical Differentiation: Expression of .-catenin and Osteopontin American Journal of Dermatopathology · 2007 · 26 citations
    3. 1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis? Journal of Investigative Dermatology · 2018
    4. An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes British Journal of Dermatology · 2019 · 19 citations
    5. Osteopontin regulatory functions in the hair follicle open a therapeutic approach for hypertrichosis British Journal of Dermatology · 2019
    6. Osteopontin Gene is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner Journal of Investigative Dermatology · 2001 · 17 citations
    7. Signalling by senescent melanocytes hyperactivates hair growth Nature · 2023 · 27 citations
    8. Osteopontin: a new facilitating factor in alopecia areata pathogenesis? PubMed · 2015 · 7 citations
    9. 695 Using MALDI-MSI analysis to study distribution of FOL-005, a potent, novel inhibitor of human hair growth, after subcutaneous injection in mice Journal of Investigative Dermatology · 2016
    10. Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis Pharmacological Research · 2024 · 5 citations
    All research on Osteopontin →

    Community 8

    1. He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years. Reddit · 20 Mar 2024
    2. Published in Nature: Osteopontin, a protein involved in the growth of hair on moles could be the key to our troubles. Reddit · 12 Jul 2023
    3. Amplifica: Hope or Cope? A Review of Their Pipeline Reddit · 17 Aug 2026
    4. Found an interesting little article Reddit · 19 Aug 2024
    5. Soundwaves & Electricity Grows Hair? | Peptide Delivery Model. Reddit · 6 Aug 2024
    6. Peptides that Stop Hair Loss? | In-depth Literature Review Video Reddit · 6 Jul 2024
    7. Expectations control for SCUBE3 Reddit · 23 Mar 2024
    8. Amplifica and AMP-303 clinical phase 1 Reddit · 20 Jan 2024
    All community posts on Osteopontin →