Keloid Pathogenesis and Fibroproliferative Properties Are Dependent on Stem Cells Regulated by the Hedgehog-Gli1 Pathway

    May 2023 in “ Research Square (Research Square) ”
    Mamiko Tosa, Yoshinori Abe, Seiko Egawa … Nobuyuki Tanaka

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    2. Hedgehog Signaling Is Essential For Normal Wound Healing Wound Repair and Regeneration · 2008
    3. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007