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Glossary Keloids

raised, thickened scar tissue that extends beyond original wounds

Keloids are raised, thickened areas of scar tissue that form at the site of skin injury, such as cuts, burns, or surgical incisions. Unlike regular scars, keloids extend beyond the original wound boundaries and can continue to grow over time. They are the result of an overproduction of collagen during the healing process and can be itchy, painful, or cause discomfort. Keloids are more common in individuals with darker skin tones and can be challenging to treat, often requiring a combination of therapies such as corticosteroid injections, laser treatment, or surgical removal.

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Research

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research Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

305 citations , March 2018 in “International journal of molecular sciences”

In this review, the authors summarize classical and recent insights into the biology and treatment of hypertrophic scars and keloids, concluding that while understanding and strategies have advanced, effective prevention and treatments remain unsatisfactory.

research Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.

research Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

35 citations , July 2018 in “BMJ Open”

This study found that patients with atopic dermatitis have a higher risk of developing keloid, suggesting it may be an independent risk factor for keloid formation.

research The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease

31 citations , March 2016 in “Journal of Investigative Dermatology”

AKR1B10 enzyme may cause keloid scars and could be a treatment target.

research New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects

21 citations , February 2015 in “Clinical Cosmetic and Investigational Dermatology”

This review explores the "brain-skin connection" and presents evidence suggesting keloids may be influenced by psychosocial stress, although it reports no new experimental results.

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Community Join

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community What Are the Technicalities of Curved Hair Transplantation?

4 upvotes 6 months ago

Curved hair transplantation requires specialized tools and techniques to avoid damaging hair follicles, with modified FUE being the preferred method. Proper extraction and implantation angles are crucial to prevent complications like keloids and sterile folliculitis.

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Learn

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learn Scalp Micropigmentation

Can scalp micropigmentation hide my scars? Providers say SMP can make scalp scars much less visible, but not invisible; this is a provider claim, not a measured result.

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