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Glossary Hypertrophic Scars

raised, thickened skin areas from excessive collagen after injury

Hypertrophic scars are raised, thickened areas of skin that form at the site of an injury or incision. Unlike keloid scars, which can grow beyond the boundaries of the original wound, hypertrophic scars remain confined to the wound area but can be red, itchy, and sometimes painful. They result from an overproduction of collagen during the healing process and can improve over time, though treatments like silicone sheets, corticosteroid injections, or laser therapy may be used to reduce their appearance.

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research Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

305 citations , March 2018 in “International journal of molecular sciences”

In this review, the authors summarize classical and recent insights into the biology and treatment of hypertrophic scars and keloids, concluding that while understanding and strategies have advanced, effective prevention and treatments remain unsatisfactory.

research A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar

47 citations , November 2012 in “Wound repair and regeneration”

This study found that grafting split-thickness human skin onto nude mice produces scars that mimic hypertrophic scar characteristics in humans, offering a useful model for studying scar formation and treatments.

research A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.

research Effect of P144® (Anti-TGF-β) in an “In Vivo” Human Hypertrophic Scar Model in Nude Mice

32 citations , December 2015 in “PloS one”

This study found that applying a topical inhibitor of TGF-β1 may enhance scar maturation and improve the appearance of hypertrophic scars in a nude mouse model after two weeks.

research Fibroblasts and endothelial cells interplay drives hypertrophic scar formation: Insights from in vitro and in vivo models

21 citations , December 2023 in “Bioengineering & Translational Medicine”

This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.

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community The Biggest Concern That I Have For Oral Minoxidil: Cardiac Hypertrophy

26 upvotes 3 years ago

Oral minoxidil can cause serious heart issues like cardiac hypertrophy and arrhythmias, prompting some users to reduce dosage or switch to topical treatments. Despite significant hair regrowth, side effects such as shortness of breath and chest pains are common concerns.

community Extreme caution: my experience using Ru58841 only once

in Treatment 10 upvotes 1 year ago

An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

community How is this even possible that there is no cure till now

in Technology 155 upvotes 4 months ago

There is no permanent cure for hair loss; treatments like finasteride, minoxidil, and hair transplants require ongoing use and are not universally effective. Genetic complexity and financial incentives for ongoing treatments hinder the development of a definitive cure.

community Update - December 2024 to May 2026. Topical fin/min

973 upvotes 4 months ago

The user experienced significant hair regrowth using a nightly topical spray with 0.3% finasteride and 6% minoxidil, without side effects. Noticeable improvements were seen within three months, with continued progress over time.

community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

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