Pharmacotherapy for Keloids and Hypertrophic Scars

    April 2024 in “ International journal of molecular sciences ”
    Teruo Murakami, Sadayuki Shigeki
    TLDR Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.
    The review article "Pharmacotherapy for Keloids and Hypertrophic Scars" highlights the challenges in treating these conditions, emphasizing that combination therapies are more effective than monotherapies. Key treatments include ACE inhibitors, tranilast, antisense drugs, interferons, calcium antagonists, chemotherapeutics, enzymes, vitamins, immunomodulators, monoclonal antibodies, botulinum toxin A, pentoxifylline, plant-based compounds, statins, and steroids. These treatments aim to reduce fibroblast proliferation, collagen production, and inflammation, promote wound healing, and induce fibroblast apoptosis. The review underscores the importance of personalized treatment plans and further research to optimize these therapies.
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