Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Trinidad Montero‐Vílchez, Álvaro Sierra-Sánchez, Manuel Sánchez‐Díaz, María I. Quiñones-Vico, Raquel Sanabria-de la Torre, Antonio Martínez-López, Salvador Arias‐Santiago
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    TLDR The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.
    The systematic review analyzed 101 studies on the therapeutic potential of mesenchymal stromal cell-conditioned medium (MSC-CM) in treating various skin diseases. MSC-CM, rich in growth factors and cytokines, showed promising results in wound healing, anti-inflammation, anti-fibrosis, and hair growth, specifically stimulating hair growth by prolonging the anagen phase of the hair cycle. The conditions treated included wound healing, hypertrophic scars, flap reperfusion, hair restoration, skin rejuvenation, and inflammatory skin diseases. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. It also reduced hypertrophic scars and flap ischemia in animal models. However, more standardized and rigorous clinical trials are needed to confirm these findings and to establish the optimal dosage and administration method for MSC-CM.
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