Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

July 2021 in “ Frontiers in Cell and Developmental Biology ”

Trinidad Montero‐Vílchez, Álvaro Sierra-Sánchez, Manuel Sánchez‐Díaz, María I. Quiñones-Vico, Raquel Sanabria-de la Torre, Antonio Martínez-López, Salvador Arias‐Santiago

mesenchymal stromal cell-conditioned medium MSC-CM growth factors cytokines hair growth anagen phase wound healing anti-inflammation anti-fibrosis hair restoration skin rejuvenation inflammatory skin diseases atopic dermatitis psoriasis hypertrophic scars flap ischemia

TLDR The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.

The systematic review analyzed 101 studies on the therapeutic potential of mesenchymal stromal cell-conditioned medium (MSC-CM) in treating various skin diseases. MSC-CM, rich in growth factors and cytokines, showed promising results in wound healing, anti-inflammation, anti-fibrosis, and hair growth, specifically stimulating hair growth by prolonging the anagen phase of the hair cycle. The conditions treated included wound healing, hypertrophic scars, flap reperfusion, hair restoration, skin rejuvenation, and inflammatory skin diseases. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. It also reduced hypertrophic scars and flap ischemia in animal models. However, more standardized and rigorous clinical trials are needed to confirm these findings and to establish the optimal dosage and administration method for MSC-CM.

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research The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment

10 citations , December 2020 in “Dermatologic Surgery”

research Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia

14 citations , November 2020 in “International Journal of Molecular Sciences”

Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

research Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

13 citations , June 2020 in “Stem Cells International”

A substance from a specific gel helped to grow hair effectively in mice, suggesting it could potentially be used to treat hair loss in humans.

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

33 citations , June 2020 in “Dermatologic Surgery”

Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations , May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.

research The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration

6 citations , April 2020 in “Applied sciences”

Hair growth medium helps heal wounds and regrow hair in mice.

research Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by Increasing Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

14 citations , November 2019 in “Mediators of inflammation”

IL-6 from stem cells helps repair skin and grow hair.

research Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration

14 citations , July 2019 in “Experimental and Molecular Medicine”

Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.

research Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation

15 citations , May 2019 in “PLOS ONE”

Substances from dental stem cells might help treat hair loss.

research Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine

88 citations , March 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

research A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

36 citations , January 2017 in “Stem Cells International”

A special stem cell fluid can speed up wound healing and hair growth in mice.

research Hair Growth-Promoting Effect of Human Dermal Stem/Progenitor Cell-Derived Conditioned Medium

9 citations , August 2015 in “Tissue Engineering and Regenerative Medicine”

Human skin cell byproducts can potentially be used to treat hair loss and promote hair growth.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , June 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research The Establishment and Characterization of Immortalized Human Dermal Papilla Cells and Their Hair Growth Promoting Effects

13 citations , December 2010 in “Journal of Dermatological Science”

Researchers made a cell line that grows quickly and can help with hair growth research.

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.