Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Trinidad Montero‐Vílchez, Álvaro Sierra-Sánchez, Manuel Sánchez‐Díaz … Salvador Arias‐Santiago
    Studysummary This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
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    Research cited in this study 22

    1. Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia International Journal of Molecular Sciences · 2020
    2. The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment Dermatologic Surgery · 2020
    3. Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice Stem Cells International · 2020
    4. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells · 2020
    5. The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration Applied sciences · 2020
    6. HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation International Journal of Molecular Sciences · 2019
    7. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by Increasing Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps Mediators of inflammation · 2019
    8. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium Dermatologic Surgery · 2019
    9. Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration Experimental and Molecular Medicine · 2019
    10. Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation PLOS ONE · 2019
    11. Conditioned Medium From Human Mesenchymal Stromal Cells: Towards Clinical Translation International Journal of Molecular Sciences · 2019
    12. Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine Journal of Tissue Engineering and Regenerative Medicine · 2019
    13. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice Stem Cells International · 2017
    14. Hair Growth-Promoting Effect of Human Dermal Stem/Progenitor Cell-Derived Conditioned Medium Tissue Engineering and Regenerative Medicine · 2015
    15. In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing Cytotherapy · 2015
    16. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    17. Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells International Journal of Molecular Sciences · 2015
    18. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    19. Prospect of Stem Cell Conditioned Medium in Regenerative Medicine BioMed Research International · 2014
    20. Human Wharton's Jelly Stem Cells and Their Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds Journal of Cellular Biochemistry · 2013
    21. The Establishment and Characterization of Immortalized Human Dermal Papilla Cells and Their Hair Growth Promoting Effects Journal of Dermatological Science · 2010
    22. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010