Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration

July 2019 in “ Experimental and Molecular Medicine ”

Junghyun Park, Eun Jung Jun, Daryeon Son, Wonjun Hong, Ji-Hoon Jang, Wonjin Yun, Byung Woo Yoon, Gwonhwa Song, In Young Kim, Seungkwon You

Nanog amniotic fluid-derived mesenchymal stem cells AF-MSCs hair follicle regeneration dermal papilla cell activity cellular senescence telogen-to-anagen transition hair follicle density hair loss alopecia stem cells hair growth hair regeneration

TLDR Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.

The study investigated the effects of overexpressing the Nanog gene in amniotic fluid-derived mesenchymal stem cells (AF-MSCs) on hair follicle regeneration. The researchers found that Nanog overexpression increased the proliferation capacity of AF-MSCs and delayed cellular senescence, while also promoting the secretion of molecules related to hair regeneration and growth. In vivo studies showed that conditioned medium derived from Nanog-overexpressing AF-MSCs accelerated the telogen-to-anagen transition in hair follicles and increased hair follicle density. The study suggests that AF-MSCs overexpressing Nanog could be a potential therapeutic option for hair loss and alopecia.

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