Overexpression of Nanog in Amniotic Fluid-Derived Mesenchymal Stem Cells Accelerates Dermal Papilla Cell Activity and Promotes Hair Follicle Regeneration

    Junghyun Park, Eun Jung Jun, Daryeon Son, Wonjun Hong, Ji-Hoon Jang, Wonjin Yun, Byung Woo Yoon, Gwonhwa Song, In Young Kim, Seungkwon You
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    TLDR Nanog gene boosts stem cells, helps hair growth, and may treat hair loss.
    The study investigated the effects of overexpressing the Nanog gene in amniotic fluid-derived mesenchymal stem cells (AF-MSCs) on hair follicle regeneration. The researchers found that Nanog overexpression increased the proliferation capacity of AF-MSCs and delayed cellular senescence, while also promoting the secretion of molecules related to hair regeneration and growth. In vivo studies showed that conditioned medium derived from Nanog-overexpressing AF-MSCs accelerated the telogen-to-anagen transition in hair follicles and increased hair follicle density. The study suggests that AF-MSCs overexpressing Nanog could be a potential therapeutic option for hair loss and alopecia.
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