BMP Signaling in the Control of Skin Development and Hair Follicle Growth

    December 2004 in “ Differentiation ”
    Vladimir A. Botchkarev, Andrey A. Sharov
    TLDR BMP signaling is crucial for skin and hair growth.
    The document discussed the role of Bone Morphogenetic Proteins (BMPs) in skin development and hair follicle growth. BMPs, their receptors, and antagonists were shown to regulate cell proliferation, differentiation, and apoptosis through BMP–Smad and BMP–MAPK pathways. In both developing and postnatal skin, BMP signaling was crucial for proper cell differentiation and hair follicle development, including initiation and cell fate decisions. Postnatally, BMPs controlled the growth phase and apoptosis-driven involution of hair follicles. The study highlighted the need for further research to fully understand BMP mechanisms and their potential therapeutic applications for skin and hair growth disorders.
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