Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis

    October 2003 in “ Developmental Biology ”
    Tammy Ellis, Ian Smyth, Emily Riley … Brandon J. Wainwright
    Studysummary This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.
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    Research cited in this study 8

    1. Suppression of Hair Follicle Development Inhibits Induction of Sonic Hedgehog, Patched, and Patched-2 in Hair Germs in Mice Archives of Dermatological Research · 2001
    2. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    3. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
    4. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    5. Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000
    6. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    7. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997
    8. The Secret Life of the Hair Follicle Trends in genetics · 1992