Suppression of Hair Follicle Development Inhibits Induction of Sonic Hedgehog, Patched, and Patched-2 in Hair Germs in Mice

    September 2001 in “ Archives of Dermatological Research ”
    Gabriela Yamago, Yoshimi Takata, Isao Furuta … Nam‐ho Huh
    Studysummary This study reported that Sonic hedgehog signaling is crucial for hair follicle development, with its expression being significantly induced in normal embryonic hair germs but inhibited in certain experimental models.
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    Research cited in this study 5

    1. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    2. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    3. Specific Inhibition of Hair Follicle Formation by Epidermal Growth Factor in an Organ Culture of Developing Mouse Skin Developmental Biology · 1997
    4. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    5. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991