Induction of Basal Cell Carcinomas and Trichoepitheliomas in Mice Overexpressing GLI-1

    March 2000 in “ Proceedings of the National Academy of Sciences ”
    Mats E. Nilsson, Anne Birgitte Undén, Darren Krause … Rune Toftgård
    Studysummary In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.
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    Research cited in this study 3

    1. Cytokeratin Expression in Trichoblastic Fibroma, Trichoepithelioma, and Basal Cell Carcinoma British Journal of Dermatology · 1999
    2. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997
    3. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992