Keratin Expression in Basal Cell Carcinomas

    February 1992 in “ British Journal of Dermatology ”
    Andrew C. Markey, E. Birgitte Lane, D.M. MACDONALD, Irene M. Leigh
    Studysummary The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.
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    Research cited in this study 2

    1. Generalized Trichoepitheliomas With Alopecia and Myasthenia Gravis: Clinicopathologic and Immunohistochemical Study and Comparison With Classic and Desmoplastic Trichoepithelioma Journal of the American Academy of Dermatology · 1986
    2. Different Keratin Polypeptides in Epidermis and Other Epithelia of Human Skin: A Specific Cytokeratin of Molecular Weight 46,000 in Epithelia of the Pilosebaceous Tract and Basal Cell Epitheliomas The Journal of Cell Biology · 1982

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    2. Keratin and Skin Disorders Cell biology international · 1996
    3. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992
    4. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989