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    Glossary Basal Keratinocytes

    cells in the skin's lowest epidermal layer producing keratin

    Basal keratinocytes are the cells located in the lowest layer of the epidermis, which is the outermost layer of the skin. These cells are responsible for producing keratin, a protein that helps protect the skin and underlying tissues. They also play a crucial role in skin regeneration by continuously dividing and pushing older cells towards the surface, where they eventually shed.

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    1. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity PloS one · 2020 · 7 citations
    2. SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes Advanced science · 2022 · 4 citations
    3. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    4. Single‐Cell Analysis of Late‐Stage Wound‐Induced Hair Follicle Neogenesis Reveals Keratinocyte Heterogeneity and Enrichment of Infundibular Basal Keratinocytes Experimental Dermatology · 2026
    5. 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile Journal of Investigative Dermatology · 2023
    6. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    7. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    8. A Murine Monoclonal Antibody (VM-1) Against Human Basal Cells Inhibits the Growth of Human Keratinocytes in Culture Journal of Investigative Dermatology · 1985 · 25 citations
    9. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    10. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
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