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    Glossary Basal Keratinocytes

    cells in the skin's lowest epidermal layer producing keratin

    Basal keratinocytes are the cells located in the lowest layer of the epidermis, which is the outermost layer of the skin. These cells are responsible for producing keratin, a protein that helps protect the skin and underlying tissues. They also play a crucial role in skin regeneration by continuously dividing and pushing older cells towards the surface, where they eventually shed.

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    1. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity PloS one · 2020 · 7 citations
    2. SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes Advanced science · 2022 · 4 citations
    3. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    4. Single‐Cell Analysis of Late‐Stage Wound‐Induced Hair Follicle Neogenesis Reveals Keratinocyte Heterogeneity and Enrichment of Infundibular Basal Keratinocytes Experimental Dermatology · 2026
    5. 1340 Basal keratinocytes exhibit age-related epigenetic and transcriptomic alterations resulting in an altered metabolic profile Journal of Investigative Dermatology · 2023
    6. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    7. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    8. A Murine Monoclonal Antibody (VM-1) Against Human Basal Cells Inhibits the Growth of Human Keratinocytes in Culture Journal of Investigative Dermatology · 1985 · 25 citations
    9. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    10. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    11. Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency Carcinogenesis · 1980 · 77 citations
    12. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    13. Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice Wound Repair and Regeneration · 2012 · 12 citations
    14. CD99 Is Strongly Expressed in Basal Cells of the Normal Adult Epidermis and Some Subpopulations of Appendages: Comparison with Developing Fetal Skin Journal of pathology and translational medicine · 2016 · 8 citations
    15. Nuclear Topology, Epigenetics, and Keratinocyte Differentiation Journal of Investigative Dermatology · 2013 · 2 citations
    16. The Expression of Vitamin D-Upregulated Protein 1 in Skin and its Interaction with Sciellin in Cultured Keratinocytes 2003 · 18 citations
    17. A Mouse Model for Conditional Expression of Activated β-Catenin in Epidermal Keratinocytes Transgenic Research · 2024 · 1 citations
    18. 874 Elevated expression of osteopontin splice variants in nonmelanoma skin cancer compared to normal skin and adult keratinocytes Journal of Investigative Dermatology · 2018
    19. 566 DermaCult™ Keratinocyte Expansion Medium, a Serum- and BPE-free Medium Supporting Long-term Feeder-free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes Journal of Investigative Dermatology · 2022
    20. Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis Journal of Investigative Dermatology · 2001 · 26 citations
    21. Expression Profile of CD10, BCL-2, p63, and EMA in the Normal Skin and Basal Cell Carcinomas: An Immunohistochemical Reappraisal Actas Dermo-Sifiliográficas · 2022 · 9 citations
    22. Isolating subpopulations of human epidermal basal cells based on polyclonal serum against trypsin-resistant CSPG4 epitopes Experimental cell research · 2016 · 2 citations
    23. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    24. Forearm hair density and risk of keratinocyte cancers in Australian adults Archives of Dermatological Research · 2016 · 11 citations
    25. Keratinocyte Cytokine Networks Associated with Human Melanocytic Nevus Development Journal of Investigative Dermatology · 2018 · 5 citations
    26. Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity 2020 · 3 citations
    27. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Publisher · 2019
    28. Abstract 1489: Basal cell carcinomas express functional indoleamine 2,3-dioxygenase (IDO) which may confer immunoprotection Cancer Research · 2010
    29. Patterns of keratinocyte carcinoma incidence on the scalp and forehead of non-alopecic women: a retrospective review Archives of Dermatological Research · 2025
    30. 54622 A characterization of US patients with keratinocyte carcinomas using DataDerm Journal of the American Academy of Dermatology · 2024