Search
for

    Glossary Keratinocyte

    cell producing keratin, forming most of the skin's outer layer

    A keratinocyte is a type of cell that makes up the majority of the outer layer of the skin, known as the epidermis. These cells produce keratin, a protein that helps protect the skin from damage, infection, and water loss. For professionals, it's important to note that keratinocytes originate in the basal layer of the epidermis and move upwards, undergoing a process of differentiation and eventually forming the stratum corneum, the outermost layer of dead cells.

    Related Terms

    Research 10 of 1000+

    1. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003 · 561 citations
    2. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    3. Location and phenotype of human adult keratinocyte stem cells of the skin Differentiation · 2004 · 233 citations
    4. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    5. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    6. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    7. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020 · 147 citations
    8. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    9. Vitamin D receptor is essential for normal keratinocyte stem cell function Proceedings of the National Academy of Sciences · 2007 · 143 citations
    10. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993 · 133 citations
    All research results →

    Community 5

    1. Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In) Community · 11 Jun 2025
    2. Comprehensive Microneedling Guide Reddit · 19 Aug 2022
    3. Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant Reddit · 30 Jul 2024
    4. Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser Reddit · 4 Mar 2024
    5. Please explain this Minoxidil phenomena Reddit · 26 Oct 2023

    Learn

    — no results

    Try a deeper search in learn →