TLDR Keratinocyte growth factor significantly alters skin and tissue development.
The study investigated the role of keratinocyte growth factor (KGF) in skin by targeting its expression to the epidermis of transgenic mice using a human keratin 14 promoter. The mice expressing KGF showed significant changes, including increased epidermal thickness, altered epidermal growth and differentiation, and suppression of hair follicle morphogenesis and adipogenesis. Additionally, some mice developed transformations in tongue epithelium and epidermis, along with elevated salivation and altered salivary gland differentiation. These findings suggested that KGF played a crucial role in mesenchymal-epithelial interactions, affecting growth, development, and differentiation of skin and other tissues.
150 citations
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August 1992 in “Genes & Development” TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
409 citations
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May 1991 in “Genes & Development” TGF-alpha affects skin thickness, hair growth, and may contribute to psoriasis and papilloma formation.
198 citations
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November 1989 in “The Journal of Cell Biology” Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.
156 citations
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January 1989 in “Genes & Development” Keratin expression reflects cell organization and differentiation, not causes it.
292 citations
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October 1985 in “The Journal of Cell Biology” Keratins and filaggrin change as fetal skin develops, marking key stages of skin formation.
112 citations
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August 1984 in “Journal of Investigative Dermatology” 124 citations
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December 1983 in “Developmental Biology” EGF receptors are crucial for skin cell growth and decrease with age.
34 citations
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January 1983 in “Journal of Investigative Dermatology”
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
113 citations
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December 2000 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” KGF and activin are crucial for skin healing and repair.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
FGF9 helps hair follicles grow in small-tailed Han sheep by affecting cell growth and certain signaling pathways.
1 citations
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January 2017 in “Elsevier eBooks” The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.
