Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity

    June 2002 in “ Molecular and Cellular Biology ”
    Charles K. Kaufman, Satrajit Sinha, Diana Bolotin … Elaine Fuchs
    Studysummary In this study, researchers identified distinct chromatin regions and regulatory elements that drive keratinocyte-specific gene expression, highlighting complex enhancer modules influencing skin epithelium through a combination of transcriptional activators and repressors.
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    Research cited in this study 8

    1. Identification and Dissection of an Enhancer Controlling Epithelial Gene Expression in Skin Proceedings of the National Academy of Sciences · 2001
    2. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    3. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    4. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    5. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    6. The Proximal Promoter of the Human Transglutaminase 3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 1996
    7. The Epidermis: Rising to the Surface Current opinion in genetics & development · 1994
    8. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993