Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis

The study utilized a technique to induce temporally controlled mutations in mouse epidermis, focusing on RXRα in adult mouse keratinocytes, to explore its role in skin physiology without the lethal effects of in utero knockout. The findings revealed that RXRα was essential for hair cycling, possibly through RXR/VDR heterodimers, and for the proliferation and differentiation of epidermal keratinocytes. This research offered new insights into the physiological functions of RXRα in the skin, overcoming challenges posed by genetic redundancies and pleiotropic effects.