Genetic Dissection of Retinoic Acid Function in Epidermis Physiology
May 2002
in “
PubMed
”
retinoic acid vitamin A RAR RXR RARa RXRbeta RARgamma RXRa RXRalpha VDR hair follicle degeneration alopecia hair follicle homeostasis VDR-null mutants RXRalpha/VDR heterodimers topical administration paracrine growth factor HB-EGF basal cells suprabasal cells RA vitamin A hair loss hair follicle health topical treatment growth factor
Studysummary This study demonstrated that mice lacking skin-specific RXRalpha expression developed hair follicle degeneration and alopecia, indicating the importance of RXRalpha/VDR heterodimers in maintaining hair follicle homeostasis.
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