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GlossaryRetinoid X Receptor (RXR)

regulates gene expression by binding to specific DNA sequences

The Retinoid X Receptor (RXR) is a type of nuclear receptor that plays a crucial role in regulating gene expression. It binds to specific DNA sequences and partners with other receptors to control various biological processes, including cell growth, differentiation, and metabolism. RXRs are important in the context of skin health and hair growth, as they can influence the activity of genes involved in these processes.

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Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Pinkie, the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRα in Th2 Development

2 citations , November 2004 in “Blood”

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

research Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis

303 citations , October 2000 in “Nature”

research Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.

143 citations , May 2002 in “PubMed”

The study demonstrated that the RXR-selective retinoid LGD1069 effectively suppressed mammary tumorigenesis in C3(1)-SV40 Tag transgenic mice without observable toxicity, unlike the RAR-selective retinoid TTNPB, which showed modest chemopreventive effects but was highly toxic. LGD1069 extended the median time to tumor development from 129 to 156 days and reduced tumor multiplicity by approximately 50% at the higher dose. In contrast, TTNPB delayed tumor development but did not affect tumor multiplicity and caused significant toxicity, including skin erythema and hair loss. These findings suggested that receptor-selective retinoids could separate cancer preventive effects from toxic effects, highlighting their potential as breast cancer prevention agents.

research An Essential Role for RXRα in the Development of Th2 Responses

50 citations , December 2005 in “European Journal of Immunology”

RXRα is crucial for proper immune response and links diet to immune function.

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 5 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 442 upvotes 4 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Dutasteride Literally Saves Your Hair

in Finasteride/Dutasteride 101 upvotes 1 year ago

Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 1 year ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.