Endogenous Retinoids in the Pathogenesis of Alopecia Areata

September 2012 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

F. Jason Duncan, Kathleen A. Silva, Claudia Johnson, Benjamin L. King, Jin P. Szatkiewicz, Sonya P. Kamdar, David E. Ong, Joseph L. Napoli, Jinshan Wang, Lloyd E. King, David Whiting, Kevin J. McElwee, John P. Sundberg, Helen B. Everts

endogenous retinoids alopecia areata retinoids vitamin A retinoic acid RA synthesis enzymes binding proteins immune regulation hair follicle biology exogenous retinoids retinoid pathways

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

vitamin A →

retinoic acid →

Studysummary This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.

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Research cited in this study

19 / 19 results

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This review examines the role of retinoic acid synthesis in hair follicles and sebaceous glands, focusing on its localization and function during normal and disease states, but reports no new results.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

61 citations , September 2010 in “Genomics”

This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Phase I/II Randomized Bilateral Half-Head Comparison of Topical Bexarotene 1% Gel for Alopecia Areata

44 citations , October 2009 in “Journal of the American Academy of Dermatology”

This study reported that 1% bexarotene gel was well tolerated and possibly effective for inducing partial hair regrowth in alopecia areata, but more rigorous trials are needed to confirm its efficacy.

research Treatment Strategies for Alopecia

34 citations , April 2009 in “Expert Opinion on Pharmacotherapy”

This review discusses evidence-based treatments for common hair loss forms, noting robust support for androgenetic alopecia therapies but limited long-term data and fewer high-quality studies for alopecia areata and cicatricial alopecias.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.

research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

24 citations , January 2008 in “KARGER eBooks”

This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.

research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.

research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that retinoic acid biosynthesis and signaling in hair follicles have a spatial and temporal regulation linked to distinct stages of the hair cycle in mice.

research Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance

21 citations , December 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.

research Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin

29 citations , January 2004 in “Experimental Dermatology”

In this study, anthralin treatment led to hair regrowth in alopecia areata-like affected C3H/HeJ mice, suggesting it may be an effective therapy for this condition.

research Interleukin-10-Deficient Mice Are Less Susceptible to the Induction of Alopecia Areata

31 citations , October 2002 in “Journal of Investigative Dermatology”

IL-10 may worsen alopecia areata instead of helping it.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

77 citations , June 2002 in “Journal of Investigative Dermatology”

CD44 variant changes start alopecia areata, but don't maintain it.

research Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

131 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that alopecia areata can be induced and serially transferred in C3H/HeJ mice using skin grafts, providing a useful model for studying the disease in humans.

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species

71 citations , January 1998 in “Pathobiology”

This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.

research Topical Tretinoin as an Adjunctive Therapy with Intralesional Triamcinolone Acetonide for Alopecia Areata: Clinical Experience in Northern Saudi Arabia

11 citations , April 1997 in “International Journal of Dermatology”

This article discusses using topical tretinoin with intralesional triamcinolone acetonide for alopecia areata in northern Saudi Arabia, but it reports no new clinical findings.

research Alopecia Areata in Aging C3H/HeJ Mice

178 citations , June 1994 in “Journal of Investigative Dermatology”

This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.