Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

    March 2007 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Helen B. Everts, John P. Sundberg, Lloyd E. King, David E. Ong
    TLDR Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.
    The study investigated the localization of enzymes, binding proteins, and receptors involved in retinoic acid (RA) synthesis and signaling during the hair cycle in C57BL/6J mice. It found that the RA biosynthesis pathway, including cellular retinol-binding protein, retinol dehydrogenase, retinal dehydrogenase 1-3, and cellular RA-binding protein 2, was present in various layers of the hair follicle, sebaceous gland, and interfollicular epidermis in a hair cycle-dependent manner. This suggests that RA biosynthesis is regulated spatially and temporally within the hair follicle, influencing hair growth, differentiation, and cycling. The study also provided new insights into epithelial-mesenchymal interactions and the differentiation states within the RA pathway, as well as the nuclear versus cytoplasmic localization of Crabp2 and RA receptors.
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