Intercellular Adhesion Molecule-1 and Hair Follicle Regression

The study demonstrated that ICAM-1 expression in murine skin was more dynamic and widespread than previously thought, with significant fluctuations during different hair cycle stages. ICAM-1 expression peaked during middle and late anagen and catagen stages, suggesting its role in hair follicle (HF) regression. ICAM-1-deficient mice showed accelerated catagen development, indicating ICAM-1's importance in controlling HF regression. The findings suggested that ICAM-1-related signaling might be crucial for HF involution and linked developmental and immunological aspects of hair growth control, providing insights into potential therapeutic targets for hair loss disorders.